Targeting partialy disordered proteins

Intrinsically disordered proteins lack stable tertiary and/or secondary structures under physiological conditions though they have key roles in cell signaling and regulation.

Numerous IDPs are associated with human diseases, including cancer, cardiovascular disease, amyloidoses, neurodegenerative diseases, and diabetes.


Elucidate order in the chaos

of intrinsically disordered proteins

By integrating AlphaFold predictions and physics based models, Euclia’s hybrid coarse grained molecular dynamics allows accurate structural ensemble identification of partially disordered proteins in hours instead of months , enabling structure based drug discovery of partially disordered proteins


A new paradign in drug discovery

From structural to structural ensemble drug discovery

Euclia's generative AI and screening methodologies generates ideal small molecule candidates for IDP's. From sequence to molecule in a matter of days.


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